Gravity is a constraint. If you're a designing an airplane, it would be a lot easier without gravity as a concern, but hey, it's not going away.
A problem is solvable. A constraint must be lived with.
For years, Apple viewed retail distribution as a constraint. They had to live with cranky independent computer stores, or big box mass merchants that didn't display or sell their products well.
Using the internet and then their own stores, they eventually realized that this was actually a problem that could be solved, and it changed everything for them.
On the other hand, there are countless entrepreneurs who believe they can solve problems relating to funding or technology that are out of reach given their scale or background. They'd be better off if they accepted them as constraints and designed around them.
The art is in telling them apart.