Lady Gaga and me
Do you think it bothers her that I don't listen to her music and wouldn't recognize her if she stopped by and said hi?
It shouldn't.
Even if you're a pop star, you don't need everyone to be a fan or a customer. And especially if you're not a pop star, worrying about whether everyone laughs at your jokes, buys your product or even likes you is counterproductive.
Unless you're running for something that requires a unanimous vote, it's a mistake to focus on the frowning guy in the back of the room or the dolt who doesn't get your subtle references or the miser who isn't going to buy from you regardless…
You're on the hunt for sneezers, for fans, for people willing to cross the street to work with you. Everyone else can pound sand, that's okay. Being remarkable also means being ignored or actively disliked.
BTW, I'm virtually certain that Lady (do her friends call her that?) doesn't read my stuff, so we're even.