You will rarely guess/create/cause #1
The breakthrough pop hit is so unpredictable that it's basically random.
You will always do better with a rational portfolio of second and third place reliable staples than you will in chasing whatever you guess that pop culture will want tomorrow.
Of course, it means giving up hoping for a miracle and instead doing the hard work of being there for the people who count on you.
[Update: It turns out the key word here is rarely. Just because I'm incapable of predicting the hits doesn't mean everyone is. I just heard from Scott Borchetta at Big Machine. He's had a #1 hit on the pop music charts every year for the last thirty. At some point, it's not luck, it's your profession.]